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Job Description
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Dr. Yu teaches physiology courses and conducts research on molecular mechanisms of neuronal signaling.
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Biosketch
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Adjunct Professor, 2004-present, Faculty of Dentistry, University of Toronto
Assistant Professor, 1998-2004, Faculty of Dentistry, University of Toronto
Research Scientist, 1998-2003, Centre for Addiction and Mental Health, Toronto |
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Education |
Dr. Scientiarum Humanarum (D.Sc.H.), 1989, University of Heidelberg, F.R.G., Neuroscience
M.Sc., 1982, Medical College of Suzhou, P.R. China, Physiology
B.M., 1977, Medical College of Xuzhou, P.R. China, Medicine |
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Honors/Awards
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2008, Ad hoc reviewer, the NIH study section “Neural Development, Plasticity and Regeneration (NDPR)”
June 2005-June 2009 (1R01 NS053567-01)
National Institutes of Health
Kinase-phosphatase complex in transducing pain signals
July 2004-June 2006 (NA5448)
Heart and Stroke Foundation of Ontario
Understanding the actions of intracellular sodium in the regulation of NMDA receptor activity and excitotoxicity
Salary awards:
1998-2003: New Investigator, Canadian Institutes of Health Research.
2002: CFI Researcher, Canada Foundation for Innovation.
1994-1996: Research Fellow, Paralyzed Veterans America (PVA), Spinal Cord Research Foundation.
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Memberships
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Verein der Freunde der Universität Heidelberg e. V.
International Association for the Study of Pain.
Society for Neuroscience.
American Association for Advancement of Science.
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Research Focus
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Ligand-gated ion channel regulation by intracellular signaling; Nociception in spinal cord and trigeminal system; Excitotoxicity and neurodegeneration.
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Publications
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1. Xu, J., Weerapura, M., Ali, K.M., Jackson, M.F., Li, H., Xue, S., Lei, G., Kwan, C.L., Manolson, M.F., MacDonald, J.F., Yang, K. and Yu, X.-M.: Control of excitatory synaptic transmission C-terminal Src Kinase. JBC 2008 (283) 17503-17514.
2. Yu, X.-M.: The role of intracellular sodium (Na+) in the regulation of NMDA receptor-mediated channel activity and toxicity. Molecular Neurobiology 2006, (33) 63-79.
3. Xin, W.-K., Zhao, X.-H., Xu, J., Kwan, C.L., Zhu, K.-M., Cho, J.S.N., Duff, M., Ellen, R.P., McCulloch, C.A.G. and Yu, X.-M.: A Novel Mechanism Underlying the Recruitment of N- Methyl-D-Aspartate Receptors in Neurotoxicity. European J. Neuroscience 2005 (21) 622-636.
4. Xin, W.-K., Kwan, C.L., Zhao, X.-H., Xu, J., Ellen, R.P., McCulloch, C.A.G. dnd Yu, X.-M.: A functional interaction of sodium and calcium in the regulation of NMDA receptor activity by remote NMDA receptors. J. Neuroscience 2005, (25) 139-148.
5. Lei, G., Xue, S., Chéry, N., Liu, Q., Xu, J.-D., Kwan, C.L., Fu, Y.P., Lu, Y.M., Liu, M.Y., Harder, K.W., and Yu, X.-M.: Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha. The EMBO J. 2002, (21) 2977-2989.
6. Lee, F.J., Xue, S., Pei, L., Vukusic, B., Chéry, N., Wang, Y., Wang, Y.T., Niznik, H.B. Yu, X.-M., and Liu, F.: Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Cell 2002 (111) 219-230.
7. Liu, F., Wan Q., Pristupa, Z.B. Yu, X.-M., Wang, Y.T. and Niznik, H.B.: Direct protein-protein coupling enables cross-talk between dopamine D5 and ?-aminobutyric acid A receptors. Nature 2000 (403) 274-280.
8. Yu, X.-M. , and Salter, M.W.: Src, a novel molecular switch governing the gain of synaptic transmission mediated by NMDA receptors. Proc. Natl. Acad. Sci. USA, 1999, (96) 7697-7704.
9. Yu, X.-M. and Salter, M.W.: The gain control of NMDA receptor mediated synaptic currents by intracellular sodium. Nature 1998 (396) 469-474.
10. Yu, X.-M. , Askalan, R., Keil II, G.L. and Salter, M.W.: NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science 1997 (275) 674-678.
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