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Job Description
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Research, Teaching and Service
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Biosketch
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Dr. Blaber graduated with a BA in Biochemistry/Molecular Biology from the University of California at Santa Barbara in 1980. At the time, molecular biology was a new field, and UCSB was one of the few institutions that offered an undergraduate degree program in this area. After graduation, Blaber was recruited by Genentech, Inc., to work as a Research Assistant in their Protein Chemistry group. Genentech was one of the first biotech startup companies, and Blaber was the 120th employee. After 5 exciting years studying the properties of recombinant human plaminogen activators, Blaber left Genentech and entered the Ph.D. program in the Department of Biological Sciences in the College of Medicine at UC Irvine (in the laboratory of Dr. Ralph A. Bradshaw). During this time Blaber studied structure/function relationships of murine glandular kallikreins, and was supported by an undergraduate NIH fellowship and an Earl C. Anthony dissertation fellowship. After graduating, Blaber was a Postdoctoral Fellow in the laboratory of Dr. Brian Matthews, Howard Hughes Medical Institute, University of Oregon. During this time, Blaber was supported by an NIH Postdoctoral Fellowship to study the structure and stability relationships of T4 lysozyme mutants. After completing his Postdoctoral work, Blaber joined the Department of Chemistry at FSU as an Assistant Professor; receiving a University Teaching Award in 1999. Blaber earned tenure, and promotion to Associate Professor in 2000. In fall 2005 Blaber joined the Department of Biomedical Sciences in the College of Medicine at FSU. In 2007 Blaber was promoted to Professor and also received the Outstanding Senior Faculty Researcher Award . |
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Education |
1976-1980 BA Biochemistry/Molecular Biology, University of California at Santa Barbara
1985-1990 Ph.D. Biological Chemistry, University of California at Irvine |
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Service
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Editorial Board:
Editorial Advisory Board, Protein Science (1/03-12/09)
Editorial Board, Molecular and Cellular Proteomics (6/01-5/07)
Peer Review:
National Science Foundation, Integrative Organismal Biology Panel Ad hoc (8/05)
National Science Foundation, Molecular Biochemistry Panel (10/04 - 10/07)
American Heart Association, Cell Function & Metabolism (10/04 - 10/05)
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Honors/Awards
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Outstanding Senior Faculty Researcher Award, Department of Biomedical Sciences, FSU (2007)
Faculty Ranking #1, Department of Chemistry & Biochemistry, FSU (2002)
University Teaching Award, FSU (1999)
First Year Assistant Professor Award, FSU (1995)
N.I.H. Postdoctoral Fellowship GM13709-01, Institute of Molecular Biology, University of Oregon, Eugene OR (3/90-2/93)
N.I.H. Predoctoral Fellowship GM07134-11, University of California, Irvine CA (9/86-8/89)
Earl C. Anthony Dissertation Fellowship, University of California, Irvine CA (9/89-12/89)
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Memberships
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American Chemical Society, Biophysical Society, Protein Society, American Association for the Advancement of Science (AAAS), Federation of American Societies for Experimental Biology (FASEB), International Union of Crystallographers (IUCr), American Society for Biochemistry & Molecular Biology (ASBMB)
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Research Focus
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Protein structure, stability and folding; Mutational study of human fibroblast growth factor 1 for angiogenic therapy; Structural biology and enzymology of human kallikrein-related peptidases; Role of human kallikrein-related peptidase 6 in human disease.
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Publications
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Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases, Yoon, H., Laxmikanthan, G., Lee, J., Blaber, S.I., Rodriguez, A., Kogot, J.M., Scarisbrick. I.A. and Blaber, M., J. Biol. Chem. (in press)
Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N- and C-terminus b-strand Interactions, Dubey, V.K., Lee, J., Somasundaram, T., Blaber, S. and Blaber, M., J. Mol. Biol. 371, 256-268 (2007)
The Autolytic Regulation of Human Kallikrein-Related Peptidase 6, Blaber, S., Yoon, H., Scarisbrick, I.A., Juliano, M.A., and Blaber, M. Biochemistry 46, 5209-5217 (2007)
Dynamic Role of Kallikrein 6 in Traumatic Spinal Cord Injury, Scarisbrick, I.A., Sabharwal, P., Blaber, S.I., Cruz, H., Ameednuddin, S., Papke, L.M., Larsen, N., Fehlings, M.G., Reeves, R.K., Blaber, M., Windebank, A.J. and Rodriguez, M., Eur. J. Neurosci. 24, 1457-1469 (2006)
Conversion of type I 4:6 to 3:5 b-turn Types in Human Acidic Fibroblast Growth Factor: Effects upon Structure, Stability, Folding and Mitogenic Function, Lee, J., Dubey, V.K., Somasundaram, T. and Blaber, M. Proteins 62, 686-697(2006)
Redesigning Symmetry-Related "Mini-Core" Regions of FGF-1 to Increase Primary Structure Symmetry: Thermodynamic and Functional Consequences of Structural Symmetry, Dubey, V.K., Lee, J. and Blaber, M., Protein Science 14:2315-2323 (2005)
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