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Johanna Paik Ph.D.
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Research Assistant Professor
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johanna.paik@med.fsu.edu
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850-645-6447
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Department of Biomedical Sciences |
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Job Description
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Dr. Paik is a research scientist studying chromatin metabolism in response to DNA damage and replication stress. She is also involved in facilitating small-group sessions with medical students.
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Biosketch
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Dr. Paik received her training in Biochemistry and Genetics at the University of Goettingen in Germany. She obtained her Diploma and Ph.D. from the Max Planck Institute for Molecular Genetics in Berlin, Germany where she worked on bacterial antibiotic resistance. From there she moved to London, UK to carry out her post-doctoral research at Cancer Research UK where she was involved in the study of chromatin metabolism in response to DNA damage, as well as carrying out cancer research using human tumor cell lines. She joined the faculty of the Department of Biomedical Sciences at Florida State University in March 2005. |
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Education |
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1995 Diploma in Biochemistry at the Max Planck Institut für Molekulare
Genetik, Berlin, Germany.
1999 Ph.D. in Microbiology at the Max Planck Institut für Molekulare
Genetik, Berlin, Germany.
1999-2005 Post-doctoral research fellow, Cancer Research UK, United Kingdom |
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Honors/Awards
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Awarded the prestigious Hoechst Fellowship for her diploma by Hoechst AG, Frankfurt, Germany.
Awarded the Cancer Research UK post-doctoral fellowship (July 1999 - Sept 2003)
Awarded the Cancer Research Technologies (UK) Research grant (Oct 2003 - Feb 2005)
PATENT: ‘Monofunctional Glycosyltransferases' - German patent registration No. 19717893.
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Research Focus
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The focus of Dr. Paik's lab is to understand how cells coordinate the synthesis of histones with the rate of ongoing DNA replication during the S-phase of the cell cycle, especially in response to replication stress or DNA damage. The prompt and orderly assembly of newly replicated DNA into chromatin is crucial for efficient replication and segregation of the chromosome. Failure to do so can lead to genomic instability which is a hallmark of cancer cells.
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Publications
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Paik, J., Reddy, G.U., Kabbaj, M.M., Verreault, A., and Gunjan, A. (2009). Checkpoint kinases repress histone gene transcription in response to genotoxic agents that impede replication. Genes & Development. (Submitted)
Singh, R.K., Kabbaj, M.M., Paik, J., and Gunjan, A. (2009). Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis. Nature Cell Biology. (In press)
Singh, R.K., Paik, J., and Gunjan, A.(2009). Generation and management of excess histones during the cell cycle. Frontiers in Bioscience. 14: 3145-3158.
Gunjan, A., Paik, J., and Verreault, A. (2006). The emergence of regulated histone proteolysis. Current Opinion in Genetics and Development, 16: 112-118.
Gunjan, A., Paik, J., and Verreault, A. (2005). Regulation of histone synthesis and nucleosome assembly. Biochimie, 87: 625-635.
J. Paik, T. Duncan, T. Lindahl, and B. Sedgwick (2005). Sensitisation of Human Tumor Cells to Alkylating Agents by small interfering RNA suppression of 3-Alkyladenine-DNA Glycosylase. Cancer Research, 65:10472-10477.
Hakenbeck, R., K. Kaminski, A. König, M. van der Linden, J. Paik, P. Reichmann, and D. Zähner (2000). Penicillin binding proteins in b-lactam resistant Streptococcus pneumoniae. In: Streptococcus pneumoniae: Molecular Biology and Mechanisms of Disease - Update for the 1990s (A. Tomasz, ed), pp 433-441. Mary Ann Liebert, Inc., Larchmont, NY.
J. Paik, I. Kern, R. Lurz, and R. Hakenbeck (1999) Mutational analysis of the Streptococcus pneumoniae bimodular class A penicillin binding proteins. J. Bacteriol., 18: 3852-3856.
J. Paik, D. Jendrossek, R. Hakenbeck (1997) A putative monofunctional glycosyltransferase is expressed in Ralstonia eutropha. J. Bacteriol., 179(12): 4061-4065.
T. Grebe, J. Paik, R. Hakenbeck. (1997) A novel resistance mechanism against ß-lactams in Streptococcus pneumoniae involves cpoA, a putative glycosyltransferase. J. Bacteriol., 179(10): 3342-3349.
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